Current Issue February 2012, Vol. 39, No. 2

Issue Highlights

Review

Introduction to the MRSA series of reviews
February 2012(Vol. 39 | No. 2 | Pages 95)
Ian Gould
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New insights into meticillin-resistant Staphylococcus aureus (MRSA) pathogenesis, treatment and resistance
February 2012(Vol. 39 | No. 2 | Pages 96-104)
Ian M. Gould, Michael Z. David, Silvano Esposito, Javier Garau, Gerard Lina, Teresita Mazzei, Georg Peters

Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: clinical impact and therapeutic options
February 2012(Vol. 39 | No. 2 | Pages 105-114)
Marie Kempf, Jean-Marc Rolain

Does empirical treatment of community-acquired pneumonia with fluoroquinolones delay tuberculosis treatment and result in fluoroquinolone resistance in Mycobacterium tuberculosis? Controversies and solutions
27 January 2012
Gwan-Han Shen, Thomas Chang-Yao Tsao, Shang-Jyh Kao, Jen-Jyh Lee, Yen-Hsu Chen, Wei-Chung Hsieh, Gwo-Jong Hsu, Yen-Tao Hsu, Ching-Tai Huang, Yeu-Jun Lau, Shih-Ming Tsao, Po-Ren Hsueh
Abstract: The role of fluoroquinolones (FQs) as empirical therapy for community-acquired pneumonia (CAP) remains controversial in countries with high tuberculosis (TB) endemicity owing to the possibil...
Cytosine deoxyribonucleoside anti-HIV analogues: a small chemical substitution allows relevant activities
24 January 2012
Francesco Scaglione, Liberato Berrino
Abstract: The search for new nucleoside analogue compounds targeting the virally encoded reverse transcriptase was developed by modifying the nucleoside structure to create inhibitor compounds. In thi...
Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically confirmed diagnosis of community-acquired pneumonia in Belgium
16 January 2012
Ann Lismond, Sylviane Carbonnelle, Jan Verhaegen, Patricia Schatt, Annelies De Bel, Paul Jordens, Frédérique Jacobs, Anne Dediste, Frank Verschuren, Te-Din Huang, Paul M. Tulkens, Youri Glupczynski, Françoise Van Bambeke
Abstract: We assessed the in vitro susceptibility of Streptococcus pneumoniae isolates from patients with confirmed community-acquired pneumonia (CAP) to β-lactams, macrolides and fluoroquinolones and...
Efficacy and mechanism of action of arachidonic acid in the treatment of hamsters infected with Schistosoma mansoni or Schistosoma haematobium
13 January 2012
Rashika El Ridi, Hatem Tallima, Mohamed Salah, Marwa Aboueldahab, Omar M. Fahmy, Mohammad Farhan Al-Halbosiy, Soheir S. Mahmoud
Abstract: We have recently shown that in vitro and in vivo exposure of Schistosoma mansoni and Schistosoma haematobium to 5–10mM arachidonic acid (ARA) induces parasite surface membrane disintegration...
Carbapenem-resistant Pseudomonas aeruginosa pneumonia with intermediate minimum inhibitory concentrations to doripenem: combination therapy with high-dose, 4-h infusion of doripenem plus fosfomycin versus intravenous colistin plus fosfomycin
11 January 2012
Anucha Apisarnthanarak, Linda M. Mundy
Alternative treatment strategies are needed to optimise the efficacy of treatment for infections due to multidrug-resistant pathogens . Pharmacokinetic and pharmacodynamic data for carbapenems, in con...

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International Journal of Antimicrobial Agents is published by Elsevier for the International Society of Chemotherapy (ISC) for Infection and Cancer.

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About International Journal of Antimicrobial Agents

International Journal of Antimicrobial Agents provides comprehensive and up-to-date peer reviewed reference information on the physical, pharmacological, in vitro and clinical properties of individual antimicrobial agents (antiviral agents, antiparasitic agents, antibacterial agents, antifungal agents, immunotherapeutic agents, etc.). In addition, the journal signals new trends and developments in the field through highly authoritative review articles on antimicrobial agents, immunomodulators and immunotherapy. Special attention is given to articles providing insight into the problems of antimicrobial resistance, local as well as world-wide, both in the hospital and in the community. Papers on the underlying mechanisms and on immunomodulating agents are also welcome. Both solicited reviews by top experts in the mentioned fields and high-quality original research papers are published.

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The general objectives of the International Society of Chemotherapy (ISC) for Infection and Cancer are to advance the education and science of chemotherapy. International congresses and conferences promoting the development of chemotherapy are held regularly. The ISC encourages, supports and sponsors the formation of international working groups for special research projects, commissions, training projects and the use of chemotherapeutics in the field of antimicrobial and antineoplastic chemotherapy. It also helps to co-ordinate the activities of these working groups.