International Journal of Antimicrobial Agents
Volume 14, Issue 3 , Pages 221-224, April 2000

Immunomodulating effect of 2,3,4,5-tetrahydro-1H-3-benzazepines (a new class of non-nucleoside inhibitors of reverse transcriptase)

  • Livia Berek

      Affiliations

    • Faculty of Medicine, Institute of Microbiology, Albert Szent-Györgyi Medical University, Dorn ter 10, 6720 Szeged, Hungary
    • Corresponding Author InformationCorresponding author. Tel.: +36-62-455115; fax: +36-62-455113
    • ,
  • Ildiko B Petri

      Affiliations

    • Blood Transfusion Center, Albert Szent-Györgyi Medical University, Dorn ter 10, 6720 Szeged, Hungary
    • ,
  • Eva Varga

      Affiliations

    • Blood Transfusion Center, Albert Szent-Györgyi Medical University, Dorn ter 10, 6720 Szeged, Hungary
    • ,
  • Joseph Molnár

      Affiliations

    • Faculty of Medicine, Institute of Microbiology, Albert Szent-Györgyi Medical University, Dorn ter 10, 6720 Szeged, Hungary
    • ,
  • Masami Kawase

      Affiliations

    • Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
    • ,
  • Setsuo Saito

      Affiliations

    • Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
    • ,
  • Noboru Motohashi

      Affiliations

    • Meiji Pharmaceutical University, Tokyo, Japan

Received 21 October 1999

Abstract 

The effects of newly synthesized, reverse transcriptase inhibitors, 3-benzazepines, for their effects on natural killer (NK) cell and blast transformation in human peripheral blood mononuclear cells were investigated. The most effective reverse transcriptase inhibitors were KF1, KF2 and KF3, which primarily suppressed immunological functions. Besides the inhibition of T cell proliferation, the benzazepines also show inhibitory effect on NK cell functions, in particularly, against large granular lymphocytes and monocytes. The B lymphocytes and Fc mediated killer functions were less inhibited.

Keywords:  2,3,4,5-Tetrahydro-1H-3-benzazepines, Reverse transcriptase, Immunomodulating effect, NK reaction, Blast transformation

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PII: S0924-8579(00)00125-4

International Journal of Antimicrobial Agents
Volume 14, Issue 3 , Pages 221-224, April 2000

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