International Journal of Antimicrobial Agents
Volume 14, Issue 3 , Pages 221-224 , April 2000

Immunomodulating effect of 2,3,4,5-tetrahydro-1H-3-benzazepines (a new class of non-nucleoside inhibitors of reverse transcriptase)

  • Livia Berek

      Affiliations

    • Faculty of Medicine, Institute of Microbiology, Albert Szent-Györgyi Medical University, Dorn ter 10, 6720 Szeged, Hungary
    • Corresponding Author InformationCorresponding author. Tel.: +36-62-455115; fax: +36-62-455113
  • ,
  • Ildiko B Petri

      Affiliations

    • Blood Transfusion Center, Albert Szent-Györgyi Medical University, Dorn ter 10, 6720 Szeged, Hungary
  • ,
  • Eva Varga

      Affiliations

    • Blood Transfusion Center, Albert Szent-Györgyi Medical University, Dorn ter 10, 6720 Szeged, Hungary
  • ,
  • Joseph Molnár

      Affiliations

    • Faculty of Medicine, Institute of Microbiology, Albert Szent-Györgyi Medical University, Dorn ter 10, 6720 Szeged, Hungary
  • ,
  • Masami Kawase

      Affiliations

    • Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
  • ,
  • Setsuo Saito

      Affiliations

    • Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
  • ,
  • Noboru Motohashi

      Affiliations

    • Meiji Pharmaceutical University, Tokyo, Japan

Received 21 October 1999

References 

  1. Nasca J, Hewlett IK, Molnár J. Antiretroviral compounds focussed on reverse transcriptase. Non Antibiot. 1998;1:357–376
  2. Hewlett IK, Lee S, Molnár J, et al.  Inhibition of HIV infection of H9 cells by chlorpromazine derivatives. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1997;15:16–20
  3. Artico M, Silvestri R, Pagnozzy E, et al.  5H-Pyrrolo[1,2,5]benzothiadiazepines (PBTDs): a novel class of non-nucleoside reverse transcriptase inhibitors. Bioorg. Med. Chem. 1996;6:837–850
  4. Kovacs T, Parnanyi L, Pelczer I, et al.  Solid-state and solution conformation of 3′-amino-3′-deoxythymidine, precusor to a noncompetitive inhibitor of HIV-1 reverse transcriptase. J. Med. Chem. 1991;34:2595–2600
  5. Taylor PB, Culp JS, Debouck C, et al.  Kinetic and mutational analysis of human immunodeficiency virus type 1, reverse transcriptase inhibition by inophyllums, a novel class of non-nucleoside inhibitors. J. Biol. Chem. 1994;9:6325–6331
  6. Schffer W, Friebe WG, Leinert H, et al.  Non nucleoside inhibitors of HIV-1 reverse transcriptase molecular modeling and X-ray structure investigations. J. Med. Chem. 1993;36:726–732
  7. Proudfoot JR, Hargrave KD, Kapadia SR. Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase 4,2-substituted dipyridodiazepinones as potent inhibitors of both wild-type and cystein-181 HIV-1 reverse transcriptase enzymes, 1995;38:4830–38.
  8. Molnár J, Szabo D, Miskolci Cs, et al.  Effect of some new 3-benzazepines on plasmid DNA, mdr P-glycoprotein and reverse transcriptase of leukaemia. Non Antibiot. 1998;1:272–280
  9. Kawase M, Motohashi N, Niwa M, et al.  Use of the triflamide group for Friedel-Crafts acylation of N-(β-phenethyl)amino acids to 3-benzazepine derivatives. Heterocycles. 1997;45:1121–1129
  10. Kawase M, Niwa M, Nozaki, et al. Synthesis of 2-trifluoromethyl-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives, Heterocycles 1998;48:555–60.
  11. Molnár J, Mandi Y, Petri I, et al.  Immuonomodulation activity of phenothiazines, benzo[a]phenothiazines. Anticancer Res. 1993;13:439–442
  12. Molnár J, Petri I, Berek I, et al.  The effects of cannabinoids and cannabispiro compounds on Escherichia coli adhesion to tissue culture cells and on leukocytes functions in vitro. Acta Microbiol. Acad. Sci. Hung. 1987;34:233–240
  13. Petri I, Szekeres E, Berek I, et al.  Effect of benzo[a]phenothiazines on natural killer cell activity of peripheral blood mononuclear cells. Anticancer Res. 1993;13:2273–2276
  14. Motohashi N, Kawase M, Saito S, et al. Plasmid elimination and immunomodulation by 3-benzazepines in vitro, Anticancer Res 1999.
  15. Weinstock J, Hieble JP, Wilson JW. The chemistry and pharmacology of 3-benzazepines. Drugs Future. 1985;10:645–696

PII: S0924-8579(00)00125-4

International Journal of Antimicrobial Agents
Volume 14, Issue 3 , Pages 221-224 , April 2000