International Journal of Antimicrobial Agents
Volume 23, Issue 6 , Pages 547-555, June 2004

Expanded-spectrum cephalosporin resistance in non-typhoid Salmonella

  • V Miriagou

      Affiliations

    • Laboratory of Bacteriology, Hellenic Pasteur Institute, Athens, Greece
    • ,
  • P.T Tassios

      Affiliations

    • Department of Microbiology, Medical School, University of Athens, M. Asias 75, Athens 11527, Greece
    • ,
  • N.J Legakis

      Affiliations

    • Department of Microbiology, Medical School, University of Athens, M. Asias 75, Athens 11527, Greece
    • ,
  • L.S Tzouvelekis

      Affiliations

    • Department of Microbiology, Medical School, University of Athens, M. Asias 75, Athens 11527, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30-210-7462152; fax: +30-210-7462011.

Abstract 

Expanded-spectrum cephalosporins (ESCs) such as ceftriaxone, together with fluorinated quinolones, are the choice antibiotics in the treatment of invasive salmonella infections. Resistance to ESCs among non-typhoid salmonella has been recognised since the late 1980s. Currently, ESC-resistant salmonella strains are reported world-wide and in some areas their incidence is significant. Resistance is mainly due to acquisition of multi-resistant plasmids encoding a variety of extended-spectrum and AmpC-type β-lactamases. The origins of ESC-resistant salmonellae are diverse. Exchange of resistance determinants between salmonellae and nosocomial enterobacteria seems to be frequent, at least in developing countries. Also, the use of newer β-lactams in animal husbandry and veterinary medicine may have facilitated the spread of ESC-resistant salmonella strains in livestock.

Keywords:  Salmonella, Resistance, Cephalosporin

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PII: S0924-8579(04)00126-8

doi:10.1016/j.ijantimicag.2004.03.006

International Journal of Antimicrobial Agents
Volume 23, Issue 6 , Pages 547-555, June 2004

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