International Journal of Antimicrobial Agents
Volume 34, Issue 3 , Pages 210-214 , September 2009

In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube

  • Shigeki Nakamura

      Affiliations

    • Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • These authors contributed equally to this work.
    • ,
  • Katsunori Yanagihara

      Affiliations

    • Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • Department of Laboratory Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • These authors contributed equally to this work.
    • Corresponding Author InformationCorresponding author. Present address: Department of Laboratory Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Tel.: +81 958 197 276; fax: +81 958 497 285.
    • ,
  • Nobuko Araki

      Affiliations

    • Department of Laboratory Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • ,
  • Yoshitomo Morinaga

      Affiliations

    • Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • Department of Laboratory Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • ,
  • Koichi Izumikawa

      Affiliations

    • Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • ,
  • Masafumi Seki

      Affiliations

    • Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • ,
  • Hiroshi Kakeya

      Affiliations

    • Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • ,
  • Yoshihiro Yamamoto

      Affiliations

    • Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • ,
  • Shimeru Kamihira

      Affiliations

    • Department of Laboratory Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • ,
  • Shigeru Kohno

      Affiliations

    • Second Department of Internal Medicine, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    • Division of Molecular & Clinical Microbiology, Department of Molecular Microbiology & Immunology, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan

Received 5 January 2009 ,Accepted 15 March 2009.

References 

  1. Everett ED, Rham AE, Adaniya R, Stevens DL, McNitt TR. Haemophilus influenzae pneumonia in adults. JAMA. 1977;238:319–321
  2. Maciver I, Silverman SH, Brown MR, O’Reilly T. Rat model of chronic lung infections caused by non-typable Haemophilus influenzae. J Med Microbiol. 1991;35:139–147
  3. Miyazaki S, Nunoya T, Matsumoto T, Tateda K, Yamaguchi K. New murine model of bronchopneumonia due to cell-bound Haemophilus influenzae. J Infect Dis. 1997;175:205–209
  4. Slater LN. A rat model of prolonged pulmonary infection due to nontypable Haemophilus influenzae. Am Rev Respir Dis. 1990;142:1429–1435
  5. Smith GM, Abbott KH. Development of experimental respiratory infections in neutropenic rats with either penicillin-resistant Streptococcus pneumoniae or β-lactamase-producing Haemophilus influenzae. Antimicrob Agents Chemother. 1994;38:608–610
  6. Yanagihara K, Tomono K, Sawai T, Hirakata Y, Kadota J, Koga H, et al. Effect of clarithromycin on lymphocytes in chronic respiratory Pseudomonas aeruginosa infection. Am J Respir Crit Care Med. 1997;155:337–342
  7. Kaneko Y, Yanagihara K, Seki M, Kuroki M, Miyazaki Y, Hirakata Y, et al. Clarithromycin inhibits overproduction of muc5ac core protein in murine model of diffuse panbronchiolitis. Am J Physiol Lung Cell Mol Physiol. 2003;285:L847–L853
  8. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing. Tenth informational supplement. M100-S10. Wayne, PA: NCCLS; 2000.
  9. Fukuda Y, Yanagihara K, Ohno H, Higashiyama Y, Miyazaki Y, Tsukamoto K, et al. In vivo efficacies and pharmacokinetics of DX-619, a novel des-fluoro(6) quinolone, against Streptococcus pneumoniae in a mouse lung infection model. Antimicrob Agents Chemother. 2006;50:121–125
  10. Murphy TF. Haemophilus infections. In:  Braunwarld F,  Fauci AS,  Kaspar DL,  Hauser SL,  Longo DL,  Jameson JL editor. Harrisons principles of internal medicine. 15th ed.. New York, NY: McGraw Hill; 2001;p. 939–942
  11. Sarangi J, Cartwright K, Stuart J, Brookes S, Morris R, Slack M, et al. Invasive Haemophilus influenzae disease in adults. Epidemiol Infect. 2000;124:441–447
  12. Wallace RJ, Musher DM, Martin RR. Hemophilus influenzae pneumonia in adults. Am J Med. 1978;64:87–93
  13. Baker AF. Bronchiectasis. N Engl J Med. 2002;346:1383–1393
  14. Murphy TF. Haemophilus influenzae in chronic bronchitis. Semin Respir Infect. 2000;15:41–51
  15. Scaglione F, Scamazzo F, Arcidiacono MM, Cogo R, Monzani GP, Fraschini F. Comparative activities of pefloxacin and ciprofloxacin in the treatment of chronic respiratory tract infections. J Chemother. 1995;2:140–145
  16. Milatovic D, Schmitz FJ, Brisse S, Verhoef J, Fluit AC. In vitro activities of sitafloxacin (DU-6859a) and six other fluoroquinolones against 8 796 clinical bacterial isolates. Antimicrob Agents Chemother. 2000;44:1102–1107
  17. Miyashita N, Niki Y, Matsushima T. In vitro and in vivo activities of sitafloxacin against Chlamydia spp.. Antimicrob Agents Chemother. 2001;45:3270–3272

PII: S0924-8579(09)00144-7

doi: 10.1016/j.ijantimicag.2009.03.011

International Journal of Antimicrobial Agents
Volume 34, Issue 3 , Pages 210-214 , September 2009

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