Letter to the Editor
PER-1-type extended-spectrum β-lactamase-producing Acinetobacter baumannii clinical isolates from India

https://doi.org/10.1016/j.ijantimicag.2009.06.006Get rights and content

Section snippets

Acknowledgments

The authors thank members of the Department of Microbiology, KEM Hospital, and geneOmbio Technologies Pvt. Ltd., Pune, India, for technical assistance. They also thank the University Grants Commission (UGC) for partly supporting the fellowship of GML.

Funding: A UGC grant was awarded to VSG and SGJ for Acinetobacter research work; GML was supported in part through this grant.

Competing interests: None declared.

Ethical approval: Not required.

References (7)

There are more references available in the full text version of this article.

Cited by (8)

  • Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: Mechanisms and epidemiology

    2015, International Journal of Antimicrobial Agents
    Citation Excerpt :

    PER-1-producing A. baumannii are also considered to be widespread in South Korea [3], Hungary [4], Romania [5], Russia [6], Belgium [7] and the USA [8]. They have also been identified in Bulgaria, India, China, Iran and Kuwait [9–13] (Table 1). In A. baumannii, the blaPER-1 gene is part of a composite transposon named Tn1213, bracketed by two different insertion sequences (ISPa12 and ISPa13) sharing similar inverted repeat sequences [14].

  • Distribution of β-lactamases in carbapenem-non-susceptible Acinetobacter baumannii in Riyadh, Saudi Arabia

    2014, Journal of Global Antimicrobial Resistance
    Citation Excerpt :

    These GES β-lactamases may have contributed to carbapenem resistance, although it is impossible to be certain since the B cluster isolates also had ISAba1-upregulated blaOXA-51-like, but the other class A ESBLs found (the PER types in clusters of A and D) are unlikely to have done so. PER ESBLs are prevalent in Acinetobacter in Saudi Arabia, United Arab Emirates, Turkey, South Korea, Russia, Romania, Belgium, France, Hungary and India [21,22,24–26]. The most common mechanism of cephalosporin resistance in A. baumannii is ISAba1-mediated upregulation of chromosomal ‘ADC’ AmpC variants [27], and this mechanism was confirmed in all of the current isolates, which, regardless of cluster, were highly resistant to cephalosporins, with MICs often ≥256 μg/mL.

  • Molecular characterization of carbapenem-insensitive Acinetobacter baumannii in Egypt

    2014, International Journal of Infectious Diseases
    Citation Excerpt :

    Our results revealed that A. baumannii were devoid of VEB, SHV, and CTX-M, but TEM and PER were detected in 87.5% and 49.1% of A. baumannii isolates, respectively. PER has been documented in Acinetobacter isolates from France, Belgium, India, Iran, South Korea, Saudi Arabia, and Argentina.4,18,45–48 PER-1, PER-2, and PER-7 have been detected previously in A. baumannii.4,45–48

  • Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: Clinical impact and therapeutic options

    2012, International Journal of Antimicrobial Agents
    Citation Excerpt :

    It is of interest that VEB-1 was located on the chromosome and was part of a class 1 integron [15]. The PER-1 gene was isolated in European countries (France, Belgium, Romania, Bulgaria and Hungary) as well as in Turkey, Russia, the USA, China, India and South Korea [1,41–46]. Recently, the ESBL PER-7 was isolated from bronchoalveolar lavage of a patient hospitalised in Paris (France) and, compared with PER-1, has been shown to possess higher hydrolytic activities against cephalosporins and aztreonam.

View all citing articles on Scopus
1

Drexel University College of Medicine, Philadelphia, USA 19102.

View full text