International Journal of Antimicrobial Agents
Volume 36, Issue 1 , Pages 66-68 , July 2010

Evaluation of azithromycin, trovafloxacin and grepafloxacin as prophylaxis against experimental murine Brucella melitensis infection

  • Helen S. Atkins

      Affiliations

    • Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 1980 614 755; fax: +44 1980 614 307.
    • ,
  • Stephen Spencer

      Affiliations

    • Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
    • ,
  • Simon D. Brew

      Affiliations

    • Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
    • ,
  • Dominic C. Jenner

      Affiliations

    • Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    • ,
  • Armine M. Sefton

      Affiliations

    • Centre for Infectious Disease, Barts and The London, Queen Mary's School of Medicine and Dentistry, Whitechapel, London E1 2AD, UK
    • ,
  • Alastair P. MacMillan

      Affiliations

    • Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
    • ,
  • Timothy J.G. Brooks

      Affiliations

    • Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    • Present address: Health Protection Agency Centre for Emergency Preparedness & Response, Porton Down, Salisbury SP4 0JG, UK.
    • ,
  • Andrew J.H. Simpson

      Affiliations

    • Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK

Received 2 October 2009 ,Accepted 2 October 2009.

References 

  1. Roushan MRH, Mohraz M, Hajlahmadi M, Ramzani A, Valayati AA. Efficacy of gentamicin plus doxycycline versus streptomycin plus doxycycline in the treatment of brucellosis in humans. Clin Infect Dis. 2006;42:1075–1080
  2. Kocagoz S, Akova M, Altun B, Gur D, Hascelik G. In vitro activities of new quinolones against Brucella melitensis isolated in a tertiary-care hospital in Turkey. Clin Microbiol Infect. 2002;8:240–242
  3. Trujillano-Martin I, Garcia-Sanchez E, Martinez IM, Fresnadillo MJ, Garcia-Sanchez JE, Garcia-Rodriguez JA. In vitro activities of six new fluoroquinolones against Brucella melitensis. Antimicrob Agents Chemother. 1999;43:194–195
  4. Landinez R, Linares J, Loza E, Martinez-Beltran J, Martin R, Baquero F. In vitro activity of azithromycin and tetracycline against 358 clinical isolates of Brucella melitensis. Eur J Clin Microbiol Infect Dis. 1992;11:265–267
  5. Akova M, Gur D, Livermore DM, Kocagoz T, Akalin HE. In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs. Antimicrob Agents Chemother. 1999;43:1298–1300
  6. Lang R, Shasha B, Ifrach N, Tinman S, Rubinstein E. Therapeutic effects of roxithromycin and azithromycin in experimental murine brucellosis. Chemotherapy. 1994;40:252–255
  7. Domingo S, Gastearena I, Vitas AI, Lopez-Goni I, Dios-Vieitez C, Diaz R, et al. Comparative activity of azithromycin and doxycycline against Brucella spp. infection in mice. J Antimicrob Chemother. 1995;36:647–656
  8. Domingo S, Gamazo C. Inadequate azithromycin activity against Brucella melitensis in mice with acute or chronic infections. J Chemother. 1996;8:55–58
  9. Atkins HS, Spencer S, Brew SD, Jenner DC, Russell P, MacMillan AP, et al. Efficacy of ciprofloxacin or doxycycline as prophylaxis against experimental murine Brucella melitensis infection. Int J Antimicrob Agents. 2009;34:474–476
  10. Atkins HS, Spencer S, Brew SD, Laws TP, Thirlwall RE, MacMillan AP, et al. Efficacy of moxifloxacin or gatifloxacin as prophylaxis against experimental murine Brucella melitensis infection. Int J Antimicrob Agents. 2009;34:471–473

☆ © Crown Copyright 2009. Published with permission of the Defence Science and Technology Laboratory on behalf of the Controller of HMSO.

PII: S0924-8579(09)00466-X

doi: 10.1016/j.ijantimicag.2009.10.003

International Journal of Antimicrobial Agents
Volume 36, Issue 1 , Pages 66-68 , July 2010

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