International Journal of Antimicrobial Agents
Volume 35, Issue 4 , Pages 338-341 , April 2010

Intrinsic fluoroquinolone resistance in Orientia tsutsugamushi

  • Wiwit Tantibhedhyangkul

      Affiliations

    • URMITE CNRS-IRD UMR 6236, Faculté de Médecine et de Pharmacie, Université de la Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    • ,
  • Emmanouil Angelakis

      Affiliations

    • URMITE CNRS-IRD UMR 6236, Faculté de Médecine et de Pharmacie, Université de la Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    • ,
  • Narongchai Tongyoo

      Affiliations

    • Wellcome Trust–Mahosot Hospital–Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic
    • ,
  • Paul N. Newton

      Affiliations

    • Wellcome Trust–Mahosot Hospital–Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic
    • Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, UK
    • ,
  • Catrin E. Moore

      Affiliations

    • Wellcome Trust–Mahosot Hospital–Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic
    • Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, UK
    • ,
  • Rattanaphone Phetsouvanh

      Affiliations

    • Wellcome Trust–Mahosot Hospital–Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic
    • Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, UK
    • ,
  • Didier Raoult

      Affiliations

    • URMITE CNRS-IRD UMR 6236, Faculté de Médecine et de Pharmacie, Université de la Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    • ,
  • Jean-Marc Rolain

      Affiliations

    • URMITE CNRS-IRD UMR 6236, Faculté de Médecine et de Pharmacie, Université de la Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 4 91 38 55 17; fax: +33 4 91 83 03 90.

Received 15 October 2009 ,Accepted 27 November 2009.

References 

  1. Phongmany S, Rolain JM, Phetsouvanh R, Blacksell SD, Soukkhaseum V, Rasachack B, et al. Rickettsial infections and fever, Vientiane, Laos. Emerg Infect Dis. 2006;12:256–262
  2. Fournier PE, Siritantikorn S, Rolain JM, Suputtamongkol Y, Hoontrakul S, Charoenwat S, et al. Detection of new genotypes of Orientia tsutsugamushi infecting humans in Thailand. Clin Microbiol Infect. 2008;14:168–173
  3. Parola P, Blacksell SD, Phetsouvanh R, Phongmany S, Rolain JM, Day NP, et al. Genotyping of Orientia tsutsugamushi from humans with scrub typhus, Laos. Emerg Infect Dis. 2008;14:1483–1485
  4. McClain JB, Joshi B, Rice R. Chloramphenicol, gentamicin, and ciprofloxacin against murine scrub typhus. Antimicrob Agents Chemother. 1988;32:285–286
  5. Cracco C, Delafosse C, Baril L, Lefort Y, Morelot C, Derenne JP, et al. Multiple organ failure complicating probable scrub typhus. Clin Infect Dis. 2000;31:191–192
  6. Lee HC, Ko WC, Lee HL, Chen HY. Clinical manifestations and complications of rickettsiosis in southern Taiwan. J Formos Med Assoc. 2002;101:385–392
  7. Jensenius M, Montelius R, Berild D, Vene S. Scrub typhus imported to Scandinavia. Scand J Infect Dis. 2006;38:200–202
  8. Mathai E, Rolain JM, Verghese L, Mathai M, Jasper P, Verghese G, et al. Case reports: scrub typhus during pregnancy in India. Trans R Soc Trop Med Hyg. 2003;97:570–572
  9. Mathai E, Rolain JM, Verghese GM, Abraham OC, Mathai D, Mathai M, et al. Outbreak of scrub typhus in southern India during the cooler months. Ann N Y Acad Sci. 2003;990:359–364
  10. Tsai CC, Lay CJ, Wang CL, Ho YH, Wang LS, Chen LK. Levofloxacin versus tetracycline antibiotics for the treatment of scrub typhus. Int J Infect Dis. 2009;[Epub ahead of print]
  11. Angelakis E, Biswas S, Taylor C, Raoult D, Rolain JM. Heterogeneity of susceptibility to fluoroquinolones in Bartonella isolates from Australia reveals a natural mutation in gyrA. J Antimicrob Chemother. 2008;61:1251–1255
  12. Biswas S, Raoult D, Rolain JM. A bioinformatic approach to understanding antibiotic resistance in intracellular bacteria through whole genome analysis. Int J Antimicrob Agents. 2008;32:207–220
  13. Kelly DJ, Salata KF, Strickman D, Hershey JN. Rickettsia tsutsugamushi infection in cell culture: antibiotic susceptibility determined by flow cytometry. Am J Trop Med Hyg. 1995;53:602–606
  14. Boulos A, Rolain JM, Maurin M, Raoult D. Measurement of the antibiotic susceptibility of Coxiella burnetii using real time PCR. Int J Antimicrob Agents. 2004;23:169–174
  15. Rolain JM, Stuhl L, Maurin M, Raoult D. Evaluation of antibiotic susceptibilities of three rickettsial species including Rickettsia felis by a quantitative PCR DNA assay. Antimicrob Agents Chemother. 2002;46:2747–2751
  16. Cho NH, Kim HR, Lee JH, Kim SY, Kim J, Cha S, et al. The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host–cell interaction genes. Proc Natl Acad Sci USA. 2007;104:7981–7986
  17. Nakayama K, Yamashita A, Kurokawa K, Morimoto T, Ogawa M, Fukuhara M, et al. The whole-genome sequencing of the obligate intracellular bacterium Orientia tsutsugamushi revealed massive gene amplification during reductive genome evolution. DNA Res. 2008;15:185–199
  18. Blacksell SD, Luksameetanasan R, Kalambaheti T, Aukkanit N, Paris DH, McGready R, et al. Genetic typing of the 56-kDa type-specific antigen gene of contemporary Orientia tsutsugamushi isolates causing human scrub typhus at two sites in north-eastern and western Thailand. FEMS Immunol Med Microbiol. 2008;52:335–342
  19. Chu H, Lee JH, Han SH, Kim SY, Cho NH, Kim IS, et al. Exploitation of the endocytic pathway by Orientia tsutsugamushi in nonprofessional phagocytes. Infect immun. 2006;74:4246–4253
  20. Hanson B. Improved plaque assay for Rickettsia tsutsugamushi. Am J Trop Med Hyg. 1987;36:631–638
  21. Jee HG, Chung MH, Lee SG, Kim IS, Chang WH. Transmission of scrub typhus by needlestick from a patient receiving pefloxacin. Scand J Infect Dis. 1996;28:411–412
  22. Eaton M, Cohen MT, Shlim DR, Innes B. Ciprofloxacin treatment of typhus. JAMA. 1989;262:772–773

PII: S0924-8579(09)00561-5

doi: 10.1016/j.ijantimicag.2009.11.019

International Journal of Antimicrobial Agents
Volume 35, Issue 4 , Pages 338-341 , April 2010

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