International Journal of Antimicrobial Agents
Volume 35, Issue 4 , Pages 347-356 , April 2010

Combination of caspofungin or anidulafungin with antimicrobial peptides results in potent synergistic killing of Candida albicans and Candida glabrata in vitro

Received 21 August 2009 ,Accepted 30 November 2009.

References 

  1. Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN, Wenzel RP. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis. 1999;29:239–244
  2. Enoch D, Ludlam H, Brown N. Invasive fungal infections: a review of epidemiology and management options. J Med Microbiol. 2006;55:809–818
  3. Gudlaugsson O, Gillespie S, Lee K, Vande Berg J, Hu J, Messer S, et al. Attributable mortality of nosocomial candidemia, revisited. Clin Infect Dis. 2003;37:1172–1177
  4. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004;39:309–317
  5. Pfaller M, Diekema D. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007;20:133–163
  6. Hancock R, Scott M. The role of antimicrobial peptides in animal defenses. Proc Natl Acad Sci USA. 2000;97:8856–8861
  7. Jenssen H, Hamill P, Hancock R. Peptide antimicrobial agents. Clin Microbiol Rev. 2006;19:491–511
  8. Denning D. Echinocandin antifungal drugs. Lancet. 2003;362:1142–1151
  9. Harris M, Mora-Montes HM, Gow NA, Coote PL. Loss of mannosylphosphate from Candida albicans cell wall proteins results in enhanced resistance to the inhibitory effect of a cationic antimicrobial peptide via reduced peptide binding to the cell surface. Microbiology. 2009;155:1058–1070
  10. Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci USA. 1987;84:5449–5453
  11. Clark D, Durell S, Maloy W, Zasloff M. Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin. J Biol Chem. 1994;269:10849–10855
  12. Dartois V, Sanchez-Quesada J, Cabezas E, Chi E, Dubbelde C, Dunn C, et al. Systemic antibacterial activity of novel synthetic cyclic peptides. Antimicrob Agents Chemother. 2005;49:3302–3310
  13. Kondejewski LH, Lee DL, Jelokhani-Niaraki M, Farmer SW, Hancock RE, Hodges RS. Optimization of microbial specificity in cyclic peptides by modulation of hydrophobicity within a defined structural framework. J Biol Chem. 2002;277:67–74
  14. Silva PI, Daffre S, Bulet P. Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the Tachyplesin family. J Biol Chem. 2000;275:33464–33470
  15. Mor A, Hani K, Nicolas P. The vertebrate peptide antibiotics dermaseptins have overlapping structural features but target specific microorganisms. J Biol Chem. 1994;269:31635–31641
  16. Yang C-R, Zhang Y, Jacob MR, Khan SI, Zhang YJ, Li XC. Antifungal activity of C-27 steroidal saponins. Antimicrob Agents Chemother. 2006;50:1710–1714
  17. MacCallum D, Odds F. Temporal events in the intravenous challenge model for experimental Candida albicans infections in female mice. Mycoses. 2005;48:151–161
  18. MacCallum DM, Castillo L, Nather K, Munro CA, Brown AJ, Gow NA, et al. Property differences among the four major Candida albicans strain clades. Eukaryot Cell. 2009;8:373–387
  19. Odds F. Synergy, antagonism, and what the chequerboard puts between them. J Antimicrob Chemother. 2003;52:1
  20. Mukherjee PK, Sheehan DJ, Hitchcock CA, Ghannoum MA. Combination treatment of invasive fungal infections. Clin Microbiol Rev. 2005;18:163–194
  21. Pappas PG, Rex JH, Sobel JD, Filler SG, Dismukes WE, Walsh TJ, et al. Guidelines for treatment of candidiasis. Clin Infect Dis. 2004;38:161–189
  22. Arikan S, Lozano-Chui M, Paetznick V, Rex JH. In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp.. Antimicrob Agents Chemother. 2002;46:245–247
  23. Luque J, Clemons K, Stevens D. Efficacy of micafungin alone or in combination against systemic murine aspergillosis. Antimicrob Agents Chemother. 2003;47:1452–1455
  24. Olson JA, Adler-Moore JP, Smith PJ, Proffitt RT. Treatment of Candida glabrata infection in immunosuppressed mice by using a combination of liposomal amphotericin B with caspofungin or micafungin. Antimicrob Agents Chemother. 2005;49:4895–4902
  25. Cuenca-Estrella M. Combinations of antifungal agents in therapy—what value are they?. J Antimicrob Chemother. 2004;54:854–869
  26. Tanida T, Rao F, Hamada T, Ueta E, Osaki T. Lactoferrin peptide increases the survival of Candida albicans-inoculated mice by upregulating neutrophil and macrophage functions, especially in combination with amphotericin B and granulocyte-macrophage colony-stimulating factor. Infect Immun. 2001;69:3883–3890
  27. Dannaoui E, Lortholary O, Dromer F. In vitro evaluation of double and triple combinations of antifungal drugs against Aspergillus fumigatus and Aspergillus terreus. Antimicrob Agents Chemother. 2004;48:970–978
  28. Thompson GR, Wiederhold NP, Vallor AC, Villareal NC, Lewis JS, Patterson TF. Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection. Antimicrob Agents Chemother. 2008;52:3783–3785
  29. Chamilos G, Lewis R, Albert N, Kontoyiannis DP. Paradoxical effect of echinocandins across Candida species in vitro: evidence for echinocandin-specific and Candida species-related differences. Antimicrob Agents Chemother. 2007;51:2257–2259
  30. Wiederhold NP, Kontoyiannis DP, Prince RA, Lewis RE. Attenuation of the activity of caspofungin at high concentrations against Candida albicans: possible role of cell wall integrity and calcineurin pathways. Antimicrob Agents Chemother. 2005;49:5146–5148
  31. Walker LA, Munro CA, de Bruijn I, Lenardon MD, McKinnon A, Gow NA. Stimulation of chitin synthesis rescues Candida albicans from echinocandins. PLoS Pathog. 2008;4:1000040

PII: S0924-8579(09)00564-0

doi: 10.1016/j.ijantimicag.2009.11.021

International Journal of Antimicrobial Agents
Volume 35, Issue 4 , Pages 347-356 , April 2010

Article Tools

* Image Usage & Resolution