International Journal of Antimicrobial Agents
Volume 35, Issue 4 , Pages 382-386 , April 2010

Mechanisms of resistance to ciprofloxacin, ampicillin/sulbactam and imipenem in Acinetobacter baumannii clinical isolates in Taiwan

  • Cheng-Hsun Chiu

      Affiliations

    • Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
    • Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    • These authors contributed equally to this work.
    • Corresponding Author InformationCorresponding author. Tel.: +886 3 328 1200; fax: +886 3 328 8957.
    • ,
  • Hao-Yuan Lee

      Affiliations

    • Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
    • Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    • These authors contributed equally to this work.
    • ,
  • Li-Yun Tseng

      Affiliations

    • Department of Molecular Biotechnology, Da-Yeh University, Changhua, Taiwan
    • ,
  • Chyi-Liang Chen

      Affiliations

    • Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    • ,
  • Ju-Hsin Chia

      Affiliations

    • Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    • ,
  • Lin-Hui Su

      Affiliations

    • Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    • ,
  • Shu-Ying Liu

      Affiliations

    • Department of Molecular Biotechnology, Da-Yeh University, Changhua, Taiwan
    • Corresponding Author InformationCorresponding author. Tel.: +886 3 328 1200; fax: +886 3 328 8957.

Received 2 September 2009 ,Accepted 4 December 2009.

References 

  1. Giamarellou H, Antoniadou A, Kanellakopoulou K. Acinetobacter baumannii: a universal threat to public health?. Int J Antimicrob Agents. 2008;32:106–119
  2. Bergogne-Berezin E, Towner KJ. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin Microbiol Rev. 1996;9:148–165
  3. Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN, Bonomo RA. Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2007;51:3471–3484
  4. Vila J, Ruiz J, Goñi P, Jimenez de Anta T. Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii. J Antimicrob Chemother. 1997;39:757–762
  5. Vila J, Ruiz J, Goñi P, Marcos A, Jimenez de Anta T. Mutation in the gyrA gene of quinolone-resistant clinical isolates of Acinetobacter baumannii. Antimicrob Agents Chemother. 1995;39:1201–1203
  6. Magnet S, Courvalin P, Lambert T. Resistance–nodulation–cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob Agents Chemother. 2001;45:3375–3380
  7. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. Seventeenth informational supplement. Document M100-S17. Wayne, PA: CLSI; 2007.
  8. Huang LY, Chen TL, Lu PL, Tsai CA, Cho WL, Chang FY, et al. Dissemination of multidrug-resistant, class 1 integron-carrying Acinetobacter baumannii isolates in Taiwan. Clin Microbiol Infect. 2008;14:1010–1019
  9. Lee JK, Lee YS, Park YK, Kim BS. Mutations in the gyrA and parC genes in ciprofloxacin-resistant clinical isolates of Acinetobacter baumannii in Korea. Microbiol Immunol. 2005;49:647–653
  10. Liu SY, Lin JY, Chu C, Su LH, Lin TY, Chiu CH. Integron-associated imipenem resistance in Acinetobacter baumannii isolated from a regional hospital in Taiwan. Int J Antimicrob Agents. 2006;27:81–84
  11. Higgins PG, Wisplinghoff H, Stefanik D, Seifert H. Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii. J Antimicrob Chemother. 2004;54:821–823
  12. Betrosian AP, FrantzeskakiF , Xanthaki A, Douzinas EE. Efficacy and safety of high-dose ampicillin/sulbactam vs. colistin as monotherapy for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia. J Infect. 2008;56:432–436
  13. Higgins PG, Fluit AC, Milatovic D, Verhoef J, Schmitz FJ. Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa. Int J Antimicrob Agents. 2003;21:409–413
  14. Hamouda A, Amyes SG. Novel gyrA and parC point mutations in two strains of Acinetobacter baumannii resistant to ciprofloxacin. J Antimicrob Chemother. 2004;54:695–696
  15. Valentine SC, Contreras D, Tan S, Real LJ, Chu S, Xu HH. Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California. J Clin Microbiol. 2008;46:2499–2507

PII: S0924-8579(10)00006-3

doi: 10.1016/j.ijantimicag.2009.12.009

International Journal of Antimicrobial Agents
Volume 35, Issue 4 , Pages 382-386 , April 2010

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