International Journal of Antimicrobial Agents
Volume 35, Issue 5 , Pages 504-506 , May 2010

Penetration of doripenem into prostatic tissue following intravenous administration in prostatectomy patients

  • Yoshiaki Yamada

      Affiliations

    • Department of Urology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan
    • ,
  • Kazuro Ikawa

      Affiliations

    • Department of Clinical Pharmacotherapy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 82 257 5296; fax: +81 82 257 5320.
    • ,
  • Kogenta Nakamura

      Affiliations

    • Department of Urology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan
    • ,
  • Kenji Mitsui

      Affiliations

    • Department of Urology, Tokoname Municipal Hospital, 4-5 Koiehonmachi, Tokoname 479-8510, Japan
    • ,
  • Masahiro Narushima

      Affiliations

    • Department of Urology, Meitetsu Hospital, 2-26-11 Sako, Nishi-ku, Nagoya 451-8511, Japan
    • ,
  • Hatsuki Hibi

      Affiliations

    • Department of Urology, Kyoritsu General Hospital, 4-33 Goban-cho, Atsuta-ku, Nagoya 456-8611, Japan
    • ,
  • Kayo Ikeda

      Affiliations

    • Department of Clinical Pharmacotherapy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    • ,
  • Norifumi Morikawa

      Affiliations

    • Department of Clinical Pharmacotherapy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
    • ,
  • Nobuaki Honda

      Affiliations

    • Department of Urology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan

Received 23 November 2009 ,Accepted 6 January 2010.

References 

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  2. Shionogi & Co. Ltd. Finibax® prescribing information (interview form), February 2008 version. Osaka, Japan: Shionogi & Co. Ltd.
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  4. Greer ND. Doripenem (Doribax): the newest addition to the carbapenems. Proc (Bayl Univ Med Cent). 2008;21:337–341
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  7. Hori T, Nakano M, Kimura Y, Murakami K. Pharmacokinetics and tissue penetration of a new carbapenem, doripenem, intravenously administered to laboratory animals. In Vivo. 2006;20:91–96
  8. Yamaoka K, Tanigawara Y, Nakagawa T, Uno T. A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobiodyn. 1981;4:879–885
  9. Drusano GL, Preston SL, Van Guilder M, North D, Gombert M, Oefelein M, et al. A population pharmacokinetic analysis of the penetration of the prostate by levofloxacin. Antimicrob Agents Chemother. 2000;44:2046–2051
  10. Charalabopoulos K, Karachalios G, Baltogiannis D, Charalabopoulos A, Giannakopoulos X, Sofikitis N. Penetration of antimicrobial agents into the prostate. Chemotherapy. 2003;49:269–279
  11. Naber KG, Adam D, Bauernfeind A, Hönig E. Imipenem/cilastatin: in vitro activity, concentrations in plasma and prostatic adenoma and therapeutic results in patients with complicated urinary tract infections. Infection. 1986;14(Suppl. 2):S122–S129
  12. Naber KG, Sörgel F. Antibiotic therapy—rationale and evidence for optimal drug concentrations in prostatic and seminal fluid and in prostatic tissue. Andrologia. 2003;35:331–335
  13. Wagenlehner FM, Weidner W, Sörgel F, Naber KG. The role of antibiotics in chronic bacterial prostatitis. Int J Antimicrob Agents. 2005;26:1–7
  14. Mouton JW, Theuretzbacher U, Craig WA, Tulkens PM, Derendorf H, Cars O. Tissue concentrations: do we ever learn?. J Antimicrob Chemother. 2008;61:235–237

PII: S0924-8579(10)00051-8

doi: 10.1016/j.ijantimicag.2010.01.008

International Journal of Antimicrobial Agents
Volume 35, Issue 5 , Pages 504-506 , May 2010

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