International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 550-552, June 2010

In vitro combined activity of amphotericin B, caspofungin and voriconazole against clinical isolates of Trichosporon asahii

  • Houmin Li

      Affiliations

    • Department of Dermatology, Peking University People's Hospital, No. 11 Xizhimen South Street, West District, Beijing 100044, People's Republic of China
    • ,
  • Qiaoyun Lu

      Affiliations

    • Department of Dermatology, Peking University First Hospital, and Research Center for Medical Mycology, Peking University, No. 8 Xishiku Street, West District, Beijing, People's Republic of China
    • ,
  • Zhe Wan

      Affiliations

    • Department of Dermatology, Peking University First Hospital, and Research Center for Medical Mycology, Peking University, No. 8 Xishiku Street, West District, Beijing, People's Republic of China
    • ,
  • Jianzhong Zhang

      Affiliations

    • Department of Dermatology, Peking University People's Hospital, No. 11 Xizhimen South Street, West District, Beijing 100044, People's Republic of China
    • Corresponding Author InformationCorresponding author. Tel.: +86 10 8832 5471; fax: +86 10 8832 8386.

Received 19 November 2009; accepted 12 January 2010. published online 08 March 2010.

Abstract 

Disseminated infections caused by Trichosporon asahii are difficult to resolve. Combination regimens with synergistic drugs could provide additional options for treating trichosporonosis. The aim of this study was to evaluate the antifungal activities of voriconazole (VCZ), caspofungin (CAS) and amphotericin B (AMB) alone or in combination in vitro against clinical isolates of T. asahii. The combined antifungal activities of VCZ, CAS and AMB against 18 clinical isolates were assessed by a chequerboard microdilution method. CAS combined with AMB showed the highest percentage of synergistic effects (89%), much higher than those of the other two combinations (AMB/VCZ and CAS/VCZ both 17%). No antagonistic effect was observed in any case. This study demonstrates that the activity of two combined antifungals, especially the combination of CAS and AMB, against T. asahii is more effective than that of a drug alone against this fungus, suggesting that combined antifungal therapy may be a potential strategy for treating disseminated trichosporonosis.

Keywords: Trichosporon asahii, Antifungal susceptibility, Drug interaction

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0924-8579(10)00058-0

doi:10.1016/j.ijantimicag.2010.01.013

International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 550-552, June 2010

Article Tools