International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 599-602 , June 2010

2-Chloroadenosine (2-CADO) treatment modulates the pro-inflammatory immune response to prevent acute lung inflammation in BALB/c mice suffering from Klebsiella pneumoniae B5055-induced pneumonia

  • Vijay Kumar

      Affiliations

    • Corresponding Author InformationCorresponding author. Present address: Faculty of Medicine, Department of Pediatrics, Sainte Justine Hospital, 3175, Cot-Sainte Catherine, University of Montreal, Montreal H3T 1C5, Quebec, Canada. Tel.: +1 514 731 0478.
  • ,
  • Kusum Harjai
  • ,
  • Sanjay Chhibber

Received 23 September 2009 ,Accepted 13 January 2010.

References 

  1. Martin C, Leone M, Viviand X, Ayen ML, Guieu R. High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock. Crit Care Med. 2000;28:3198–3202
  2. Harada N, Okajima K, Murakami K, Usune S, Sato C, Ohshima K, et al. Adenosine and selective A2A receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation. J Pharmacol Exp Ther. 2000;294:1034–1042
  3. Cavalcante IC, Castro MV, Barreto ARF, Sullivan GW, Vale M, Almeida PRC, et al. Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis. Infect Immun. 2006;74:2606–2612
  4. Held TK, Mielke MEA, Chedid M, Unger M, Trautman M, Huhn D, et al. Granulocyte colony-stimulating factor worsens the outcome of experimental Klebsiella pneumoniae pneumonia through direct interaction with the bacteria. Blood. 1998;91:2525–2533
  5. Yadav V, Sharma S, Harjai K, Mohan H, Chhibber S. Induction and resolution of lobar pneumonia following intranasal instillation with Klebsiella pneumoniae in mice. Indian J Med Res. 2003;118:47–52
  6. Reutershan J, Cagina RE, Chang D, Linden J, Ley K. Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2A stimulation in lipopolysaccharide-induced lung injury. J Immunol. 2007;179:1254–1263
  7. Takahashi HK, Wagaki HI, Hamano R, Wake H, Kanke T, Liu K, et al. Effects of adenosine on adhesion molecule expression and cytokine production in human PBMC depend on the receptor subtype activated. Br J Pharmacol. 2007;150:816–822
  8. Haskó G, Szabó C, Németh ZH, Kvetan V, Pastores C, Vizi ES. Adenosine receptor agonists differentially regulate IL-10, TNF-α and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J Immunol. 1996;157:4634–4640
  9. Delclaux C, Azoulay E. Inflammatory response to infectious pulmonary injury. Eur Respir J. 2003;22(Suppl. 42):10s–14s
  10. Mosmann TR. Properties and function of interleukin-10. Adv Immunol. 1994;56:1
  11. Sakamaki FA, Ishizaka TU, Sayama K, Nakamura H, Terashima T, Waki Y, et al. Attenuation by intravenous 2-chloroadenosine of acute lung injury induced by live Escherichia coli or latex particles added to endotoxin in the neutropenic state. J Lab Clin Med. 2003;142:128–135
  12. Chen L, Fredholm BB, Jondal M. Adenosine, through the A1 receptor, inhibits vesicular MHC class I cross-presentation by resting DC. Mol Immunol. 2008;45:2247–2254

PII: S0924-8579(10)00059-2

doi: 10.1016/j.ijantimicag.2010.01.014

International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 599-602 , June 2010