First description of Klebsiella pneumoniae clinical isolates carrying both qnrA and qnrB genes in Portugal☆
Received 12 November 2009; accepted 14 January 2010. published online 04 March 2010.
Abstract
In the present study, 21 multidrug-resistant Klebsiella pneumoniae isolates were recovered from patients hospitalised in the Intensive Care Unit of Hospital Infante D. Pedro in Aveiro, Portugal. Fifteen isolates carried qnr genes. Four strains harboured the quinolone resistance genes qnrA and qnrB, both located on a large plasmid in two strains (KP4 and KP10) and on different plasmids in two strains (KP5 and KP6). These findings indicate an extremely high prevalence of qnr genes associated with various mobile elements such as ISCR1 and class 1 integrons.
aUniversity of Aveiro, Department of Biology, CESAM, 3810-193 Aveiro, Portugal
bSchool of Medicine, Department of Medical Microbiology, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
cHospital Infante D. Pedro EPE, 3810 Aveiro, Portugal
dCenter of Pharmaceutical Sciences, University of Coimbra, Health Sciences Campus, Faculty of Pharmacy, Department of Microbiology, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
Corresponding author. Present address: CESAM & Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal. Tel.: +351 234 370 970; fax: +351 234 372 587.
☆ This work was presented in part at the 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) and the 46th Annual Meeting of the Infectious Diseases Society of America (IDSA), 25–28 October 2008, Washington DC.
ABSTRACT