International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 584-586, June 2010

First description of Klebsiella pneumoniae clinical isolates carrying both qnrA and qnrB genes in Portugal☆

  • Sónia Ferreira

      Affiliations

    • University of Aveiro, Department of Biology, CESAM, 3810-193 Aveiro, Portugal
    • School of Medicine, Department of Medical Microbiology, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    • Hospital Infante D. Pedro EPE, 3810 Aveiro, Portugal
    • ,
  • Mark Toleman

      Affiliations

    • School of Medicine, Department of Medical Microbiology, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    • ,
  • Elmano Ramalheira

      Affiliations

    • Hospital Infante D. Pedro EPE, 3810 Aveiro, Portugal
    • ,
  • Gabriela J. Da Silva

      Affiliations

    • Center of Pharmaceutical Sciences, University of Coimbra, Health Sciences Campus, Faculty of Pharmacy, Department of Microbiology, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
    • ,
  • Timothy Walsh

      Affiliations

    • School of Medicine, Department of Medical Microbiology, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    • ,
  • Sónia Mendo

      Affiliations

    • University of Aveiro, Department of Biology, CESAM, 3810-193 Aveiro, Portugal
    • Corresponding Author InformationCorresponding author. Present address: CESAM & Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal. Tel.: +351 234 370 970; fax: +351 234 372 587.

Received 12 November 2009; accepted 14 January 2010. published online 04 March 2010.

Abstract 

In the present study, 21 multidrug-resistant Klebsiella pneumoniae isolates were recovered from patients hospitalised in the Intensive Care Unit of Hospital Infante D. Pedro in Aveiro, Portugal. Fifteen isolates carried qnr genes. Four strains harboured the quinolone resistance genes qnrA and qnrB, both located on a large plasmid in two strains (KP4 and KP10) and on different plasmids in two strains (KP5 and KP6). These findings indicate an extremely high prevalence of qnr genes associated with various mobile elements such as ISCR1 and class 1 integrons.

Keywords: qnr genes, Quinolone resistance, Klebsiella pneumoniae

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

☆ This work was presented in part at the 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) and the 46th Annual Meeting of the Infectious Diseases Society of America (IDSA), 25–28 October 2008, Washington DC.

PII: S0924-8579(10)00064-6

doi:10.1016/j.ijantimicag.2010.01.019

International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 584-586, June 2010

Article Tools