International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 587-589 , June 2010

In vitro activity of tigecycline in Plasmodium falciparum culture-adapted strains and clinical isolates from Gabon

  • Jana Held

      Affiliations

    • Institut für Tropenmedizin, Eberhard Karls Universität, Wilhelmstraße 27, 72074 Tübingen, Germany
    • These two authors contributed equally to this work.
    • ,
  • Philipp Zanger

      Affiliations

    • Institut für Tropenmedizin, Eberhard Karls Universität, Wilhelmstraße 27, 72074 Tübingen, Germany
    • These two authors contributed equally to this work.
    • ,
  • Saadou Issifou

      Affiliations

    • Unité de Recherches Médicales, Hôpital Albert Schweitzer, BP 118, Lambaréné, Gabon
    • ,
  • Peter G. Kremsner

      Affiliations

    • Institut für Tropenmedizin, Eberhard Karls Universität, Wilhelmstraße 27, 72074 Tübingen, Germany
    • Unité de Recherches Médicales, Hôpital Albert Schweitzer, BP 118, Lambaréné, Gabon
    • ,
  • Benjamin Mordmüller

      Affiliations

    • Institut für Tropenmedizin, Eberhard Karls Universität, Wilhelmstraße 27, 72074 Tübingen, Germany
    • Unité de Recherches Médicales, Hôpital Albert Schweitzer, BP 118, Lambaréné, Gabon
    • Corresponding Author InformationCorresponding author. Tel.: +49 7071 298 0240; fax: +49 7071 295 189.

Received 17 November 2009 ,Accepted 11 February 2010.

References 

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  8. Olson MW, Ruzin A, Feyfant E, Rush TS, O’Connell J, Bradford PA. Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006;50:2156–2166
  9. Bauer G, Berens C, Projan SJ, Hillen W. Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA. J Antimicrob Chemother. 2004;53:592–599
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  12. Pradines B, Rogier C, Fusai T, Mosnier J, Daries W, Barret E, et al. In vitro activities of antibiotics against Plasmodium falciparum are inhibited by iron. Antimicrob Agents Chemother. 2001;45:1746–1750
  13. Pradines B, Spiegel A, Rogier C, Tall A, Mosnier J, Fusai T, et al. Antibiotics for prophylaxis of Plasmodium falciparum infections: in vitro activity of doxycycline against Senegalese isolates. Am J Trop Med Hyg. 2000;62:82–85
  14. Starzengruber P, Thriemer K, Haque R, Khan WA, Fuehrer HP, Siedl A, et al. Antimalarial activity of tigecycline, a novel glycylcycline antibiotic. Antimicrob Agents Chemother. 2009;53:4040–4042
  15. Agwuh KN, MacGowan A. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006;58:256–265

PII: S0924-8579(10)00074-9

doi: 10.1016/j.ijantimicag.2010.02.003

International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 587-589 , June 2010

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