International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 527-530 , June 2010

In vitro evaluation of ceftaroline alone and in combination with tobramycin against hospital-acquired meticillin-resistant Staphylococcus aureus (HA-MRSA) isolates

  • Céline Vidaillac

      Affiliations

    • Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    • ,
  • Steve N. Leonard

      Affiliations

    • Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    • School of Medicine, Wayne State University, Detroit, MI 48201, USA
    • ,
  • Michael J. Rybak

      Affiliations

    • Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA
    • School of Medicine, Wayne State University, Detroit, MI 48201, USA
    • Detroit Receiving Hospital, Detroit, MI 48201, USA
    • Corresponding Author InformationCorresponding author. Present address: Anti-Infective Research Laboratory, Pharmacy Practice – 4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA. Tel.: +1 313 577 4376; fax: +1 313 577 8915.

Received 4 January 2010 ,Accepted 1 February 2010.

References 

  1. Livermore DM. Can β-lactams be re-engineered to beat MRSA?. Clin Microbiol Infect. 2006;12(Suppl. 2):11–16
  2. Sievert DM, Rudrik JT, Patel JB, McDonald LC, Wilkins MJ, Hageman JC. Vancomycin-resistant Staphylococcus aureus in the United States, 2002–2006. Clin Infect Dis. 2008;46:668–674
  3. Ge Y, Biek D, Talbot GH, Sahm DF. In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. Antimicrob Agents Chemother. 2008;52:3398–3407
  4. Miranda-Novales G, Leanos-Miranda BE, Vilchis-Perez M, Solorzano-Santos F. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin Microbiol Antimicrob. 2006;5:25
  5. Clinical and Laboratory Standards Institute. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard. 8th ed. Document M07-A8. Wayne, PA: CLSI; 2008.
  6. Leonard SN, Cheung CM, Rybak MJ. Activities of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated and hospital-associated methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2008;52:2974–2976
  7. Chin JN, Jones RN, Sader HS, Savage PB, Rybak MJ. Potential synergy activity of the novel ceragenin, CSA-13, against clinical isolates of Pseudomonas aeruginosa, including multidrug-resistant P. aeruginosa. J Antimicrob Chemother. 2008;61:365–370
  8. Meka VG, Gold HS. Antimicrobial resistance to linezolid. Clin Infect Dis. 2004;39:1010–1015
  9. Hayden MK, Rezai K, Hayes RA, Lolans K, Quinn JP, Weinstein RA. Development of daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus. J Clin Microbiol. 2005;43:5285–5287

PII: S0924-8579(10)00080-4

doi: 10.1016/j.ijantimicag.2010.02.006

International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 527-530 , June 2010

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