International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 590-592 , June 2010

Prevalence and molecular mechanism of macrolide resistance in β-haemolytic streptococci in The Netherlands

  • C.C. Van Leer Buter

      Affiliations

    • Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 24 361 0602.
    • ,
  • J.W. Mouton

      Affiliations

    • Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Ziekenhuis, Nijmegen, The Netherlands
    • ,
  • C.H.W. Klaassen

      Affiliations

    • Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Ziekenhuis, Nijmegen, The Netherlands
    • ,
  • C.M.A. Handgraaf

      Affiliations

    • Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • S. Sunnen

      Affiliations

    • Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • W.J.G. Melchers

      Affiliations

    • Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • ,
  • P.D.J. Sturm

      Affiliations

    • Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Received 4 August 2009 ,Accepted 10 February 2010.

References 

  1. Amezaga M, McKenzie H. Molecular epidemiology of macrolide resistance in β-haemolytic streptococci of Lancefield groups A, B, C and G and evidence for a new mef element in group G streptococci that carries allelic variants of mef and msr(D). J Antimicrob Chemother. 2006;57:443–449
  2. Bingen E, Leclercq R, Fitoussi F, Brahimi N, Malbruny B, Deforche D, et al. Emergence of group A streptococcus strains with different mechanisms of macrolide resistance. Antimicrob Agents Chemother. 2002;46:1199–1203
  3. Poyart C, Jardy L, Quesne G, Berche P, Trieu-Cuot P. Genetic basis of antibiotic resistance in Streptococcus agalactiae strains isolated in a French hospital. Antimicrob Agents Chemother. 2003;47:794–797
  4. Klomberg D, de Valk H, Mouton J, Klaassen C. Rapid and reliable real-time PCR assay for detection of the macrolide efflux gene and subsequent discrimination between its distinct subclasses mef(A) and mef(E). J Microbiol Methods. 2005;60:269–273
  5. Pérez-Trallero E, Montes M, Orden B, Tamayo E, García-Arenzana J, Marimón J. Phenotypic and genotypic characterization of Streptococcus pyogenes isolates displaying the MLSB phenotype of macrolide resistance in Spain, 1999 to 2005. Antimicrob Agents Chemother. 2007;51:1228–1233
  6. Arpin C, Daube H, Tessier F, Quentin C. Presence of mefA and mefE genes in Streptococcus agalactiae. Antimicrob Agents Chemother. 1999;43:944–946
  7. Muller A, Valkenburg-van den Berg A, Kreft D, Oostvogel P, Sprij A, van Belkum A. Low rate of carriage of macrolide-resistant group B streptococci in pregnant women in The Netherlands. Eur J Obstet Gynecol Reprod Biol. 2008;137:17–20
  8. Marimón J, Valiente A, Ercibengoa M, García-Arenzana J, Pérez-Trallero E. Erythromycin resistance and genetic elements carrying macrolide efflux genes in Streptococcus agalactiae. Antimicrob Agents Chemother. 2005;49:5069–5074
  9. Gherardi G, Imperi M, Baldassarri L, Pataracchia M, Alfarone G, Recchia S, et al. Molecular epidemiology and distribution of serotypes, surface proteins, and antibiotic resistance among group B streptococci in Italy. J Clin Microbiol. 2007;45:2909–2916
  10. Buxbaum A, Forsthuber S, Sauermann R, Gattringer R, Graninger W, Georgopoulos A. Development of macrolide-resistance and comparative activity of telithromycin in streptococci in Austria, 1996–2002. Int J Antimicrob Agents. 2004;24:397–400
  11. Broyles LN, Van Beneden C, Beall B, Facklam R, Shewmaker PL, Malpiedi P, et al. Population-based study of invasive disease due to β-hemolytic streptococci of groups other than A and B. Clin Infect Dis. 2009;48:706–712
  12. Merino Díaz L, Torres Sánchez M, Aznar Martín J. Prevalence and mechanisms of erythromycin and clindamycin resistance in clinical isolates of β-haemolytic streptococci of Lancefield groups A, B, C and G in Seville, Spain. Clin Microbiol Infect. 2008;14:85–87
  13. Kataja J, Seppälä H, Skurnik M, Sarkkinen H, Huovinen P. Different erythromycin resistance mechanisms in group C and group G streptococci. Antimicrob Agents Chemother. 1998;42:1493–1494
  14. Leclercq R. Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications. Clin Infect Dis. 2002;34:482–492

PII: S0924-8579(10)00084-1

doi: 10.1016/j.ijantimicag.2010.02.010

International Journal of Antimicrobial Agents
Volume 35, Issue 6 , Pages 590-592 , June 2010

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