International Journal of Antimicrobial Agents
Volume 36, Issue 2 , Pages 151-154 , August 2010

Efflux pumps may play a role in tigecycline resistance in Burkholderia species

  • Ranjith Rajendran

      Affiliations

    • Section of Infection and Immunity, Glasgow Dental School, Faculty of Medicine, University of Glasgow, 378 Sauchiehall Street, Glasgow G2 3JZ, UK
    • ,
  • Ryan F. Quinn

      Affiliations

    • Section of Infection and Immunity, Glasgow Dental School, Faculty of Medicine, University of Glasgow, 378 Sauchiehall Street, Glasgow G2 3JZ, UK
    • ,
  • Colin Murray

      Affiliations

    • Section of Infection and Immunity, Glasgow Dental School, Faculty of Medicine, University of Glasgow, 378 Sauchiehall Street, Glasgow G2 3JZ, UK
    • ,
  • Elaine McCulloch

      Affiliations

    • Department of Microbiology, Royal Hospital for Sick Children, Glasgow, UK
    • ,
  • Craig Williams

      Affiliations

    • Department of Microbiology, Royal Hospital for Sick Children, Glasgow, UK
    • ,
  • Gordon Ramage

      Affiliations

    • Section of Infection and Immunity, Glasgow Dental School, Faculty of Medicine, University of Glasgow, 378 Sauchiehall Street, Glasgow G2 3JZ, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 141 211 9752; fax: +44 141 353 1593.

Received 22 February 2010 ,Accepted 8 March 2010.

References 

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  2. Davies JC, Rubin BK. Emerging and unusual Gram-negative infections in cystic fibrosis. Semin Respir Crit Care Med. 2007;28:312–321
  3. Bouchillon SK, Hoban DJ, Johnson BM, Stevens TM, Dowzicky MJ, Wu DH, et al. In vitro evaluation of tigecycline and comparative agents in 3049 clinical isolates: 2001 to 2002. Diagn Microbiol Infect Dis. 2005;51:291–295
  4. Dean CR, Visalli MA, Projan SJ, Sum PE, Bradford PA. Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1. Antimicrob Agents Chemother. 2003;47:972–978
  5. Milatovic D, Schmitz FJ, Verhoef J, Fluit AC. Activities of the glycylcycline tigecycline (GAR-936) against 1,924 recent European clinical bacterial isolates. Antimicrob Agents Chemother. 2003;47:400–404
  6. Marquez B. Bacterial efflux systems and efflux pumps inhibitors. Biochimie. 2005;87:1137–1147
  7. Pages JM, Amaral L. Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria. Biochim Biophys Acta. 2009;1794:826–833
  8. Pages JM, Masi M, Barbe J. Inhibitors of efflux pumps in Gram-negative bacteria. Trends Mol Med. 2005;11:382–389
  9. Lomovskaya O, Warren MS, Lee A, Galazzo J, Fronko R, Lee M, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 2001;45:105–116
  10. Guglierame P, Pasca MR, De Rossi E, Buroni S, Arrigo P, Manina G, et al. Efflux pump genes of the resistance–nodulation–division family in Burkholderia cenocepacia genome. BMC Microbiol. 2006;6:66
  11. Bina XR, Philippart JA, Bina JE. Effect of the efflux inhibitors 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-β-naphthylamide on antimicrobial susceptibility and virulence factor production in Vibrio cholerae. J Antimicrob Chemother. 2009;63:103–108
  12. Chan YY, Tan TM, Ong YM, Chua KL. BpeAB-OprB, a multidrug efflux pump in Burkholderia pseudomallei. Antimicrob Agents Chemother. 2004;48:1128–1135
  13. Peleg AY, Adams J, Paterson DL. Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii. Antimicrob Agents Chemother. 2007;51:2065–2069
  14. Hirakata Y, Kondo A, Hoshino K, Yano H, Arai K, Hirotani A, et al. Efflux pump inhibitors reduce the invasiveness of Pseudomonas aeruginosa. Int J Antimicrob Agents. 2009;34:343–346

PII: S0924-8579(10)00132-9

doi: 10.1016/j.ijantimicag.2010.03.009

International Journal of Antimicrobial Agents
Volume 36, Issue 2 , Pages 151-154 , August 2010

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