International Journal of Antimicrobial Agents
Volume 36, Issue 2 , Pages 114-118 , August 2010

Characterisation of carbapenem-resistant Acinetobacter baumannii outbreak strains producing OXA-58 in Turkey

  • Canan Kulah

      Affiliations

    • Department of Microbiology and Clinical Microbiology, Medical Faculty, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey
    • These two authors contributed equally to this study.
    • Corresponding Author InformationCorresponding author. Tel.: +90 532 445 3250; fax: +90 372 261 0155.
    • ,
  • Marlies J. Mooij

      Affiliations

    • Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands
    • These two authors contributed equally to this study.
    • Present address: BIOMERIT Research Centre, Microbiology Department, University College Cork, National University of Ireland, Cork, Ireland.
    • ,
  • Fusun Comert

      Affiliations

    • Department of Microbiology and Clinical Microbiology, Medical Faculty, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey
    • ,
  • Elif Aktas

      Affiliations

    • Department of Microbiology and Clinical Microbiology, Medical Faculty, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey
    • ,
  • Guven Celebi

      Affiliations

    • Department of Infectious Diseases and Clinical Microbiology, Medical Faculty, Zonguldak Karaelmas University, Turkey
    • ,
  • Nagihan Ozlu

      Affiliations

    • Department of Microbiology and Clinical Microbiology, Medical Faculty, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey
    • ,
  • Martine C. Rijnsburger

      Affiliations

    • Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands
    • ,
  • Paul H.M. Savelkoul

      Affiliations

    • Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands

Received 16 September 2009 ,Accepted 8 March 2010.

References 

  1. Poirel L, Nordmann P. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin Microbiol Infect. 2006;12:826–836
  2. Dalla-Costa LM, Coelho JM, Souza HA, Castro ME, Stier CJ, Bragagnolo KL, et al. Outbreak of carbapenem-resistant Acinetobacter baumannii producing the OXA-23 enzyme in Curitiba, Brazil. J Clin Microbiol. 2003;41:3403–3406
  3. Héritier C, Dubouix A, Poirel L, Marty N, Nordmann P. A nosocomial outbreak of Acinetobacter baumannii isolates expressing the carbapenem-hydrolysing oxacillinase OXA-58. J Antimicrob Chemother. 2005;55:115–118
  4. Pournaras S, Markogiannakis A, Ikonomidis A, Kondyli L, Bethimouti K, Maniatis AN, et al. Outbreak of multiple clones of imipenem-resistant Acinetobacter baumannii isolates expressing OXA-58 carbapenemase in an intensive care unit. J Antimicrob Chemother. 2006;57:557–561
  5. Poirel L, Lebessi E, Héritier C, Patsoura A, Foustoukou M, Nordmann P. Nosocomial spread of OXA-58-positive carbapenem-resistant Acinetobacter baumannii isolates in a paediatric hospital in Greece. Clin Microbiol Infect. 2006;12:1138–1141
  6. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. Sixteenth informational supplement. Document M100-S16. Wayne, PA: CLSI; 2006.
  7. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial disk susceptibility tests; approved standard. 10th ed. Document M02-A10. Wayne, PA: CLSI; 2009.
  8. Savelkoul PHM, Aarts HJM, de Haas J, Dijkshoorn L, Duim B, Otsen M, et al. Amplified-fragment length polymorphism analysis: the state of an art. J Clin Microbiol. 1999;37:3083–3091
  9. Koeleman JGM, Stoof J, Biesmans DJ, Sabelkoul PHM, Vandenbroucke-Grauls CM. Comparison of amplified ribosomal DNA restriction analysis, random amplified polymorphic DNA analysis, and amplified fragment length polymorphism fingerprinting for identification of Acinetobacter genomic species and typing of Acinetobacter baumannii. J Clin Microbiol. 1998;36:2522–2529
  10. Woodford N, Ellington MJ, Coelho JM, Turton JF, Ward ME, Brown S, et al. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp.. Int J Antimicrob Agents. 2006;27:351–353
  11. Mendes RE, Kiyota KA, Monteiro J, Castanheira M, Andrade SS, Gales AC, et al. Rapid detection and identification of metallo-β-lactamase-encoding genes by multiplex real-time PCR assay and melt curve analysis. J Clin Microbiol. 2007;45:544–547
  12. Brown S, Young HK, Amyes SGB. Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina. Clin Microbiol Infect. 2005;11:15–23
  13. Coelho JM, Turton JF, Kaufmann ME, Glover J, Woodford N, Warner M, et al. Occurrence of carbapenem-resistant Acinetobacter baumannii clones at multiple hospitals in London and Southeast England. J Clin Microbiol. 2006;44:3623–3627
  14. Coelho J, Woodford N, Afzal-Shah M, Livermore D. Occurrence of OXA-58-like carbapenemases in Acinetobacter spp. collected over 10 years in three continents. Antimicrob Agents Chemother. 2006;50:756–758
  15. Bogaerts P, Naas T, Wybo I, Bauraing C, Soetens O, Piérard D, et al. Outbreak of infection by carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-58 in Belgium. J Clin Microbiol. 2006;44:4189–4192
  16. Zarrilli R, Casillo R, Di Popolo A, Tripodi MF, Bagattini M, Cuccurullo S, et al. Molecular epidemiology of a clonal outbreak of multidrug-resistant Acinetobacter baumannii in a university hospital in Italy. Clin Microbiol Infect. 2007;13:481–489
  17. Marque S, Poirel L, Heriteir C, Brisse S, Blasco MD, Filip R, et al. Regional occurrence of plasmid-mediated carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter spp. in Europe. J Clin Microbiol. 2005;43:4885–4888
  18. Vahaboglu H, Budak F, Kasap M, Gacar G, Torol S, Karadenizli A, et al. High prevalence of OXA-51-type class D β-lactamases among ceftazidime-resistant clinical isolates of Acinetobacter spp.: co-existence with OXA-58 in multiple centres. J Antimicrob Chemother. 2006;58:537–542
  19. Gur D, Korten V, Unal S, Deshpande LM, Castanheira M. Increasing carbapenem resistance due to the clonal dissemination of oxacillinase (OXA-23 and OXA-58)-producing Acinetobacter baumannii: report from the Turkish SENTRY Program sites. J Med Microbiol. 2008;57:1529–1532
  20. van Dessel H, Dijkshoorn L, van der Reijden T, Bakker N, Paauw A, van den Broek , et al. Identification of a new geographically widespread multiresistant Acinetobacter baumannii clone from European hospitals. Res Microbiol. 2004;155:105–112
  21. Hanlon GW. The emergence of multidrug resistant Acinetobacter species: a major concern in the hospital setting. Lett Appl Microbiol. 2005;41:375–378
  22. Turton JF, Kaufmann ME, Warner M, Coelho J, Dijkshoorn L, van der Reijden T, et al. A prevalent, multiresistant clone of Acinetobacter baumannii in Southeast England. J Hosp Infect. 2004;58:170–179
  23. Urban C, Segal-Maurer S, Rahal JJ. Considerations in control and treatment of nosocomial infections due to multidrug-resistant Acinetobacter baumannii. Clin Infect Dis. 2003;36:1268–1274

PII: S0924-8579(10)00150-0

doi: 10.1016/j.ijantimicag.2010.03.017

International Journal of Antimicrobial Agents
Volume 36, Issue 2 , Pages 114-118 , August 2010

Article Tools

* Image Usage & Resolution