International Journal of Antimicrobial Agents
Volume 36, Issue 3 , Pages 243-246, September 2010

Synergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolates

  • Pattarachai Kiratisin

      Affiliations

    • Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok-Noi, Bangkok 10700, Thailand
    • Corresponding Author InformationCorresponding author. Tel.: +66 2 419 7058; fax: +66 2 411 3106.
    • ,
  • Anucha Apisarnthanarak

      Affiliations

    • Division of Infectious Diseases, Faculty of Medicine, Thammasat University Hospital, Pratumthani 12120, Thailand
    • ,
  • Srirumpa Kaewdaeng

      Affiliations

    • Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok-Noi, Bangkok 10700, Thailand

Received 19 February 2010; accepted 29 April 2010. published online 14 June 2010.

Abstract 

Treatment options for multidrug-resistant (MDR) and extensively drug-resistant (XDR) Acinetobacter baumannii have been seriously limited and may require combination antimicrobial therapy. In this study, we searched for synergistic activity between carbapenems (doripenem, imipenem and meropenem) and various non-traditional agents (cefoperazone/sulbactam, doxycycline, rifampicin, netilmicin and moxifloxacin) against 40 A. baumannii clinical isolates, including MDR and XDR isolates. The results showed that combination of each carbapenem with cefoperazone/sulbactam, based on the Etest method, demonstrated synergy more frequently (17.5–32.5%) than the other tested agents, which may suggest a role in combination therapy against highly resistant A. baumannii.

Keywords: Carbapenems, Combination therapy, Synergy, Acinetobacter baumannii

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PII: S0924-8579(10)00199-8

doi:10.1016/j.ijantimicag.2010.04.011

International Journal of Antimicrobial Agents
Volume 36, Issue 3 , Pages 243-246, September 2010

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