International Journal of Antimicrobial Agents
Volume 36, Issue 3 , Pages 243-246 , September 2010

Synergistic activities between carbapenems and other antimicrobial agents against Acinetobacter baumannii including multidrug-resistant and extensively drug-resistant isolates

  • Pattarachai Kiratisin

      Affiliations

    • Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok-Noi, Bangkok 10700, Thailand
    • Corresponding Author InformationCorresponding author. Tel.: +66 2 419 7058; fax: +66 2 411 3106.
    • ,
  • Anucha Apisarnthanarak

      Affiliations

    • Division of Infectious Diseases, Faculty of Medicine, Thammasat University Hospital, Pratumthani 12120, Thailand
    • ,
  • Srirumpa Kaewdaeng

      Affiliations

    • Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok-Noi, Bangkok 10700, Thailand

Received 19 February 2010 ,Accepted 29 April 2010.

References 

  1. Abbo A, Carmeli Y, Navon-Venezia S, Siegman-Igra Y, Schwaber MJ. Impact of multi-drug-resistant Acinetobacter baumannii on clinical outcomes. Eur J Clin Microbiol Infect Dis. 2007;26:793–800
  2. Mendes RE, Bell JM, Turnidge JD, Castanheira M, Jones RN. Emergence and widespread dissemination of OXA-23, -24/40 and -58 carbapenemases among Acinetobacter spp. in Asia-Pacific nations: report from the SENTRY surveillance program. J Antimicrob Chemother. 2009;63:55–59
  3. Lee NY, Wang CL, Chuang YC, Yu WL, Lee HC, Chang CM, et al. Combination carbapenem–sulbactam therapy for critically ill patients with multidrug-resistant Acinetobacter baumannii bacteremia: four case reports and an in vitro combination synergy study. Pharmacotherapy. 2007;27:1506–1511
  4. Principe L, D’Arezzo S, Capone A, Petrosillo N, Visca P. In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii. Ann Clin Microbiol Antimicrob. 2009;8:18
  5. Pankuch GA, Lin G, Seifert H, Appelbaum PC. Activity of meropenem with and without ciprofloxacin and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii. Antimicrob Agents Chemother. 2008;52:333–336
  6. Kiffer CR, Sampaio JL, Sinto S, Oplustil CP, Koga PC, Arruda AC, et al. In vitro synergy test of meropenem and sulbactam against clinical isolates of Acinetobacter baumannii. Diagn Microbiol Infect Dis. 2005;52:317–322
  7. Appleman MD, Belzberg H, Citron DM, Heseltine PN, Yellin AE, Murray J, et al. In vitro activities of nontraditional antimicrobials against multiresistant Acinetobacter baumannii strains isolated in an intensive care unit outbreak. Antimicrob Agents Chemother. 2000;44:1035–1040
  8. Jung R, Husain M, Choi MK, Fish DN. Synergistic activities of moxifloxacin combined with piperacillin–tazobactam or cefepime against Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii clinical isolates. Antimicrob Agents Chemother. 2004;48:1055–1057
  9. Timurkaynak F, Can F, Azap OK, Demirbilek M, Arslan H, Karaman SO. In vitro activities of non-traditional antimicrobials alone or in combination against multidrug-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii isolated from intensive care units. Int J Antimicrob Agents. 2006;27:224–228
  10. White RL, Burgess DS, Manduru M, Bosso JA. Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test. Antimicrob Agents Chemother. 1996;40:1914–1918
  11. Falagas ME, Karageorgopoulos DE. Pandrug resistance (PDR), extensive drug resistance (XDR), and multidrug resistance (MDR) among Gram-negative bacilli: need for international harmonization in terminology. Clin Infect Dis. 2008;46:1121–1122
  12. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. Nineteenth informational supplement. Document M100-S19. Wayne, PA: CLSI; 2009.
  13. Bonapace CR, White RL, Friedrich LV, Bosso JA. Evaluation of antibiotic synergy against Acinetobacter baumannii: a comparison with Etest, time-kill, and checkerboard methods. Diagn Microbiol Infect Dis. 2000;38:43–50
  14. Eliopoulos GM, Moellering RC. Antimicrobial combinations. In:  Lorian V editors. Antibiotics in laboratory medicine. 4th ed.. Baltimore, MD: Williams & Wilkins; 1996;

PII: S0924-8579(10)00199-8

doi: 10.1016/j.ijantimicag.2010.04.011

International Journal of Antimicrobial Agents
Volume 36, Issue 3 , Pages 243-246 , September 2010

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