International Journal of Antimicrobial Agents
Volume 36, Issue 3 , Pages 205-210 , September 2010

Guideline for phenotypic screening and confirmation of carbapenemases in Enterobacteriaceae

  • James Cohen Stuart

      Affiliations

    • Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, The Netherlands
    • Corresponding Author InformationCorresponding author. Present address: Department of Medical Microbiology, Internal post number G04-614, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Tel.: +31 6 2127 7988.
    • ,
  • Maurine A. Leverstein-Van Hall

      Affiliations

    • Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, The Netherlands
    • Centre for Infectious Disease Control, National Institute for Public Health and the Environment [Rijksinstituut voor Volksgezondheid en Milieu (RIVM)], Bilthoven, The Netherlands
    • ,
  • on behalf of members of the Dutch Working Party on the Detection of Highly Resistant Microorganisms

      Affiliations

    • Members of the Working Party on the Detection of Highly Resistant Organisms are Nashwan Al Naiemi, Alex van Belkum, Marc Bonten, James Cohen Stuart, Marjolein Kluytmans, Jan Kluytmans, Maurine A. Leverstein-Van Hall, Christina Vandenbroucke-Grauls, Greet Vos and Andreas Voss.

References 

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  2. Souli M, Galani I, Antoniadou A, Papadomichelakis E, Poulakou G, Panagea T, et al. An outbreak of infection due to β-lactamase Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae in a Greek University Hospital: molecular characterization, epidemiology, and outcomes. Clin Infect Dis. 2010;50:364–373
  3. Queenan AM, Bush K. Carbapenemases: the versatile β-lactamases. Clin Microbiol Rev. 2007;20:440–458table of contents
  4. Falcone M, Mezzatesta ML, Perilli M, Forcella C, Giordano A, Cafiso V, et al. Infections with VIM-1 metallo-β-lactamase-producing Enterobacter cloacae and their correlation with clinical outcome. J Clin Microbiol. 2009;47:3514–3519
  5. Pasteran F, Mendez T, Guerriero L, Rapoport M, Corso A. Sensitive screening tests for suspected class A carbapenemase production in species of Enterobacteriaceae. J Clin Microbiol. 2009;47:1631–1639
  6. Tenover FC, Kalsi RK, Williams PP, Carey RB, Stocker S, Lonsway D, et al. Carbapenem resistance in Klebsiella pneumoniae not detected by automated susceptibility testing. Emerg Infect Dis. 2006;12:1209–1213
  7. Woodford N, Dallow JW, Hill RL, Palepou MF, Pike R, Ward ME, et al. Ertapenem resistance among Klebsiella and Enterobacter submitted in the UK to a reference laboratory. Int J Antimicrob Agents. 2007;29:456–459
  8. Lolans K, Calvert K, Won S, Clark J, Hayden MK. Direct ertapenem disk screening method for identification of KPC-producing Klebsiella pneumoniae and Escherichia coli in surveillance swab specimens. J Clin Microbiol. 2010;48:836–841
  9. Vading M, Samuelsen O, Haldorsen B, Sundsfjord A, Giske C. Comparison of disc diffusion, Etest, and Vitek 2 for detection of carbapenemase producing Klebsiella pneumoniae with EUCAST and CLSI breakpoint systems. In: 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 9–13 April 2010, Vienna, Austria. Basel, Switzerland: ESCMID; 2010;
  10. Walsh TR, Bolmstrom A, Qwarnstrom A, Gales A. Evaluation of a new Etest for detecting metallo-β-lactamases in routine clinical testing. J Clin Microbiol. 2002;40:2755–2759
  11. Miriagou V, Cornaglia G, Edelstein M, Galani I, Giske CG, Gniadkowski M, et al. Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues. Clin Microbiol Infect. 2010;16:112–122
  12. Pasteran F, Mendez T, Rapoport M, Guerriero L, Corso A. Controlling false-positive results obtained with the Hodge and Masuda assays for detection of class A carbapenemase in species of Enterobacteriaceae by incorporating boronic acid. J Clin Microbiol. 2010;48:1323–1332
  13. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. Nineteenth informational supplement. Document M100-S19. Wayne, PA: CLSI; 2010.
  14. Dallenne C, Da Costa A, Decre D, Favier C, Arlet G. Development of a set of multiplex PCR assays for the detection of genes encoding important β-lactamases in Enterobacteriaceae. J Antimicrob Chemother. 2010;65:490–495
  15. Lomaestro BM, Tobin EH, Shang W, Gootz T. The spread of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae to upstate New York. Clin Infect Dis. 2006;43:e26–e28
  16. Mathers AJ, Cox HL, Bonatti H, Kitchel B, Brassinga AK, Wispelwey B, et al. Fatal cross infection by carbapenem-resistant Klebsiella in two liver transplant recipients. Transpl Infect Dis. 2009;11:257–265
  17. Daikos GL, Karabinis A, Paramythiotou E, Syriopoulou VP, Kosmidis C, Avlami A, et al. VIM-1-producing Klebsiella pneumoniae bloodstream infections: analysis of 28 cases. Int J Antimicrob Agents. 2007;29:471–473
  18. Daikos GL, Petrikkos P, Psichogiou M, Kosmidis C, Vryonis E, Skoutelis A, et al. Prospective observational study of the impact of VIM-1 metallo-β-lactamase on the outcome of patients with Klebsiella pneumoniae bloodstream infections. Antimicrob Agents Chemother. 2009;53:1868–1873

PII: S0924-8579(10)00232-3

doi: 10.1016/j.ijantimicag.2010.05.014

International Journal of Antimicrobial Agents
Volume 36, Issue 3 , Pages 205-210 , September 2010

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