International Journal of Antimicrobial Agents
Volume 36, Issue 4 , Pages 380-382 , October 2010

Pentamidine inhibits Coxiella burnetii growth and 23S rRNA intron splicing in vitro

Received 19 March 2010 ,Accepted 27 May 2010.

References 

  1. Moos A, Hackstadt T. Comparative virulence of intra- and interstrain lipopolysaccharide variants of Coxiella burnetii in the guinea pig model. Infect Immun. 1987;55:1144–1150
  2. Maurin M, Raoult D. Q fever. Clin Microbiol Rev. 1999;12:518–553
  3. Regis E. The biology of doom: the history of America's secret germ warfare project. New York, NY: Henry Holt & Co.; 1999;
  4. Karakousis PC, Trucksis M, Dumler JS. Chronic Q fever in the United States. J Clin Microbiol. 2006;44:2283–2287
  5. Raoult D, Houpikian P, Dupont HT, Riss JM, Arditi-Djiane J, Brouqui P. Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine. Arch Intern Med. 1999;159:167–173
  6. Raghavan R, Miller SR, Hicks LD, Minnick MF. The unusual 23S rRNA gene of Coxiella burnetii: two self-splicing group I introns flank a 34-base-pair exon, and one element lacks the canonical omegaG. J Bacteriol. 2007;189:6572–6579
  7. Miletti KE, Leibowitz MJ. Pentamidine inhibition of group I intron splicing in Candida albicans correlates with growth inhibition. Antimicrob Agents Chemother. 2000;44:958–966
  8. Coleman SA, Fischer ER, Howe D, Mead DJ, Heinzen RA. Temporal analysis of Coxiella burnetii morphological differentiation. J Bacteriol. 2004;186:7344–7352
  9. Conte JE, Upton RA, Lin ET. Pentamidine pharmacokinetics in patients with AIDS with impaired renal function. J Infect Dis. 1987;156:885–890
  10. Raghavan R, Hicks LD, Minnick MF. A unique group I intron in Coxiella burnetii is a natural splice mutant. J Bacteriol. 2009;191:4044–4046
  11. Rolain J-M, Maurin M, Raoult D. Bacteriostatic and bactericidal activities of moxifloxacin against Coxiella burnetii. Antimicrob Agents Chemother. 2001;45:301–302
  12. Bronner U, Doua F, Ericsson Ö, Gustafsson LL, Miézan TW, Rais M, et al. Pentamidine concentrations in plasma, whole blood and cerebrospinal fluid during treatment of Trypanosoma gambiense infection in Côte d’lvoire. Trans R Soc Trop Med Hyg. 1991;85:608–611
  13. Zhang Y, Bell A, Perlman PS, Leibowitz MJ. Pentamidine inhibits mitochondrial intron splicing and translation in Saccharomyces cerevisiae. RNA. 2000;6:937–951
  14. Zhang Y, Li Z, Pilch DS, Leibowitz MJ. Pentamidine inhibits catalytic activity of group I intron Ca.LSU by altering RNA folding. Nucleic Acids Res. 2002;30:2961–2971
  15. Glaumann H, Bronner U, Ericsson Ö, Gustafsson LL, Rombo L. Pentamidine accumulates in rat liver lysosomes and inhibits phospholipid degradation. Pharmacol Toxicol. 1994;74:17–22

PII: S0924-8579(10)00236-0

doi: 10.1016/j.ijantimicag.2010.05.017

International Journal of Antimicrobial Agents
Volume 36, Issue 4 , Pages 380-382 , October 2010