International Journal of Antimicrobial Agents
Volume 39, Issue 2 , Pages 124-129 , February 2012

An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis

  • Khadijo Osman

      Affiliations

    • Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29–39 Brunswick Square, Bloomsbury, London WC1N 1AX, UK
    • Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, Bloomsbury, London WC1E 7HX, UK
  • ,
  • Dimitrios Evangelopoulos

      Affiliations

    • Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, Bloomsbury, London WC1E 7HX, UK
    • Centre for Clinical Microbiology, Department of Infection, Royal Free Campus, University College London, London NW3 2PF, UK
  • ,
  • Chandrakala Basavannacharya

      Affiliations

    • Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, Bloomsbury, London WC1E 7HX, UK
  • ,
  • Antima Gupta

      Affiliations

    • Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, Bloomsbury, London WC1E 7HX, UK
  • ,
  • Timothy D. McHugh

      Affiliations

    • Centre for Clinical Microbiology, Department of Infection, Royal Free Campus, University College London, London NW3 2PF, UK
  • ,
  • Sanjib Bhakta

      Affiliations

    • Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, Bloomsbury, London WC1E 7HX, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 207 631 6355; fax: +44 207 631 6246.
  • ,
  • Simon Gibbons

      Affiliations

    • Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29–39 Brunswick Square, Bloomsbury, London WC1N 1AX, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 207 753 5913; fax: +44 207 753 5909.

Received 27 June 2011 ,Accepted 21 September 2011.

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PII: S0924-8579(11)00402-X

doi: 10.1016/j.ijantimicag.2011.09.018

International Journal of Antimicrobial Agents
Volume 39, Issue 2 , Pages 124-129 , February 2012