International Journal of Antimicrobial Agents
Volume 14, Issue 3 , Pages 203-207 , April 2000

Synthesis and biological activity of N-acylphenothiazines

  • Noboru Motohashi

      Affiliations

    • Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-424-958953; fax: +81-424-958953
    • ,
  • Masami Kawase

      Affiliations

    • Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
    • ,
  • Setsuo Saito

      Affiliations

    • Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
    • ,
  • Teruo Kurihara

      Affiliations

    • Faculty of Science, Josai University, Saitama, Japan
    • ,
  • Kazue Satoh

      Affiliations

    • Analysis Center, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    • ,
  • Hideki Nakashima

      Affiliations

    • Department of Microbiology and Immunology, Kagoshima University Dental School, Kagoshima, Japan
    • ,
  • Mariappan Premanathan

      Affiliations

    • Department of Microbiology and Immunology, Kagoshima University Dental School, Kagoshima, Japan
    • ,
  • Rieko Arakaki

      Affiliations

    • Department of Microbiology and Immunology, Kagoshima University Dental School, Kagoshima, Japan
    • ,
  • Hiroshi Sakagami

      Affiliations

    • Department of Dental Pharmacology, Meikai University School of Dentistry, Saitama, Japan
    • ,
  • Joseph Molnár

      Affiliations

    • Institute of Microbiology, Albert Szent-Györgyi Medical University, Dóm tér 10, H-6720 Szeged, Hungary

References 

  1. Sakagami H, Satoh K, Ohata H, Takahashi H, Yoshida H, Iida M, et al. Relationship between ascorbyl radical intensity and apoptosis-inducing activity. Anticancer Res. 1996;16:2635–2644
  2. Sakagami H, Satoh K, Hatano T, Yoshida T, Okuda T. Possible role of radical intensity and oxidation potential for gallic acid-induced apoptosis. Anticancer Res. 1997;17:377–380
  3. Satoh K, Sakagami H, Kadofuku T, Kurihara T, Motohashi N. Radical intensity and carcinogenic activity of benz[c]acridines. Anticancer Res. 1997;17:3553–3558
  4. Kawase M, Motohashi N, Kurihara T, Inagaki M, Satoh K, Sakagami H. Relationship between radical intensity and cytotoxic activity of dopamine-related compounds. Anticancer Res. 1998;18:1069–1074
  5. Nogaki A, Satoh K, Iwasaka K, Takano H, Takahama M, Ida Y, et al. Radical intensity and cytotoxic activity of curcumin and gallic acid. Anticancer Res. 1998;18:3487–3491
  6. Lin G, Midha KK, Hawes EM. Synthesis of the piperidinone metabolites of piperidine type phenothiazine antipsychotic drugs via Ruthenium tetroxide oxidation. J. Heterocyclic Chem. 1991;28:215–219
  7. Nakashima H, Murakami T, Yamamoto N, Sakagami H, Tanuma S, Hatano T, et al. Inhibition of human immunodeficiency viral replication by tannins and related compounds. Antiviral Res. 1992;18:91–103
  8. Satoh K, Sakagami H, Motohashi N. Radical modulation activity of benzo[a]phenothiazine. Anticancer Res. 1997;17:2539–2544
  9. Satoh K, Sakagami H, Kurihara T, Motohashi N. Radical intensity and differentiation-inducing activity of benzo[a]phenothiazines and phenothiazines. Anticancer Res. 1997;17:2465–2470
  10. Liu JY, Lin SJ, Lin JK. Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH3T3 cells. Carcinogenesis. 1993;14:857–861
  11. Korutla L, Kumar R. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim. Biophys. Acta. 1994;1224:597–600
  12. Huang TS, Lee SC, Lin JK. Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. Proc. Natl. Acad. Sci. USA. 1991;88:5292–5296
  13. Sakagami H, Satoh K. Prooxidant action of two antioxidants: ascorbic acid and gallic acid. Anticancer Res. 1997;17:221–224
  14. Sakagami H, Satoh K, Kadofuku T, Takeda M. Methionine oxidation and apoptosis induction by ascorbate, gallate and hydrogen peroxide. Anticancer Res. 1997;17:2565–2570
  15. Sakagami H, Satoh K, Ida Y, Hosaka M, Arakawa H, Maeda M. Interaction between sodium ascorbate and dopamine. Free Radic. Biol. Med. 1998;25:1013–1020

PII: S0924-8579(99)00156-9

International Journal of Antimicrobial Agents
Volume 14, Issue 3 , Pages 203-207 , April 2000

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