International Journal of Antimicrobial Agents
Volume 14, Issue 3 , Pages 209-213, April 2000

Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia

  • Jette E Kristiansen

      Affiliations

    • Department of Clinical Microbiology, County of Sønderjylland, 6400 Sønderborg, Sygehus, Denmark
    • Corresponding Author InformationCorresponding author. Tel.: +45-74-18-2740; fax: +45-74-18-2743
    • ,
  • John Bondo Hansen

      Affiliations

    • Novo Nordisk A/S, Medicinal Chemistry, Health Care Discovery, Novo Nordisk Park, DK-2760 Måløv, Denmark

Abstract 

A series of neuroleptic agents and their structural isomers have been tested as inhibitors of HIV-replication. At non-toxic concentrations, cis (Z)- and trans (E)-flupentixol and several derivatives of the 5HT-uptake-inhibitors paroxetine and femoxetine, inhibit HIV-1 replication. The findings indicated that these compounds could be used in combination with other anti-retroviral therapy in HIV-1 infected patients with AIDS-related dementia.

Keywords:  Neuroleptic agents, AIDS, Dementia

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PII: S0924-8579(99)00157-0

International Journal of Antimicrobial Agents
Volume 14, Issue 3 , Pages 209-213, April 2000

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